Acute chikungunya virus infection and asthma.
نویسندگان
چکیده
From March 2005 to June 2006, Réunion Island, a French overseas territory in the Indian Ocean, faced an explosive chikungunya outbreak (a mosquito-borne disease caused by an alphavirus of the Togaviridae family). It was estimated that about 300,000 people were affected by the disease [1]. Many patients experienced related chikungunya disease symptoms (fever, polyarthralgia, skin rashes, diarrhoea, vomiting). To date, there are no studies describing a respiratory tract involvement due to chikungunya infection. During this period, many patients complained of respiratory symptoms such as de novo dyspnoea or a worsening of various respiratory symptoms in patients with asthma. We hypothesised that acute chikungunya infection (ACI) may induce airway hyperresponsiveness (AHR) and therefore increases symptoms of asthma.
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REFERENCES 1 Renault P, Solet JL, Sissoko D, et al. A major epidemic of chikungunya virus infection on Reunion Island, France, 2005– 2006. Am J Trop Med Hyg 2007; 77: 727–731. 2 Laurent P, Le Roux K, Grivard P, et al. Development of a sensitive real-time reverse transcriptase PCR assay with an internal control to detect and quantify chikungunya virus. Clin Chem 2007; 53: 1408–1414. 3 Johnston S...
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عنوان ژورنال:
- The European respiratory journal
دوره 35 6 شماره
صفحات -
تاریخ انتشار 2010